Round 6 is the final opening round before teams embark on their European adventures, and with big injury news coming out of the Exeter camp with Jonny Hill and Sam Simmonds set for extended stays on the sideline, don't be afraid to drop a few points on a few replacements; chances are plenty of others will be doing the same!
One to watch
Wasps welcome Gloucester to the Ricoh on Saturday in what promises to be an entertaining fixture, and at the forefront of the side will be their talismanic scrum half, Dan Robson. Ever a high performing player, he is expected to amass a great points score this weekend, though the returning Thomas Young is hot on his heels.
Team to watch
While Bath face an uphill challenge at home to Exeter, they have fielded one of the best tight-fives in the competition, all of whom have been in or around the England squad. Combine that with a dynamic back row, and there looks set to be a mighty battle up front in this fixture, and a strong haul of fantasy points.
Top captain pick
Fantasy coaches always dread to hear injury news, and it is all the more frustrating when that player is your go to captain pick, but with players like Dan Robson, Maro Itoje and George Ford expected to go well this weekend, there are still plenty of options. Top pick at the moment: Don Armand.
Top value pick
Northampton face off at Twickenham against local rivals Leicester on Saturday, with twenty-three year old David Ribbans the pick of their value players. After several strong performances so far this season, he looks set to be one of the best value players available at the moment.
Food for though
There are some real gems appearing in the game, with several players' performances far exceeding their salary, and the next few weeks are a great time to search them out. Once internationals come round and you release your top paid stars, those gems will become a great addition to your squad.
As ever, good luck to everyone, and let us know on Twitter or Facebook how you get on!